Tissue processing prepares fixed tissue for embedding in paraffin wax. The tissue passes through dehydrating and clearing reagents before paraffin infiltrates it. This allows the sample to be embedded, cut into thin sections, stained, and examined by a pathologist.

Good tissue processing preserves the structure of a sample and makes it possible to produce sections suitable for microscopic examination. Consistent processing helps pathologists assess tissue features that may be relevant and necessary for diagnosis.

The main steps are dehydration, clearing, and paraffin infiltration, following fixation. Labs can process tissue manually or use an automated tissue processor, such as Revos. Automated systems use different approaches to move tissue or reagents through each stage, with protocols selected according to the specimen and your lab’s workflow.

Epredia offers tissue processors, embedding equipment, reagents, and paraffin for the histology workflow. Tissue processors include Revos, Excelsior AS, and STP 120, giving labs options for different processing needs.

Our portfolio represents the entire histology workflow, from specimen collection to processing, sectioning to staining, and advanced imaging to archiving. Every second of every hour of every day, 48 of our products are employed in the battle against cancer. Customers put their trust in Epredia over a billion times every year.

Lab's can elevate their results with rotational tissue processing. This new innovative design is engineered for advanced molecular and immunohistochemistry needs.

The Revos rotational tissue processor delivers fast, reliable protocols, with its unique canted chamber and basket design, enabling superior sample quality, even for fatty or challenging tissues. Labs can count on Revos for diagnostic confidence and superior sample quality for IHC and molecular testing.

Histology reagents help preserve and prepare tissue so pathologists can examine its structure and make a diagnosis. Their quality and concentration throughout processing can affect sample quality. 

The Revos tissue processor provides best-in-class reagent management, automatically measuring alcohol concentration during processing, triggering reagent rotation, and ensuring each sample is exposed to the highest quality reagents while reducing manual checks, dilutions, and transfers. The result is a more consistent workflow that allows lab staff more time for other tasks.

Revos rotational technology allows your laboratory to unlock diagnostic confidence in tissue processing, even with fatty tissue samples. Revos’ innovative tilted canted chamber and in-process reagent management ensure efficient dehydration and exceptional results in as little as 9 hours. 

Globally, leading labs trust Revos for challenging specimens, achieving outstanding morphology and supporting diagnostic confidence in every run. 

Read our clinical study brief to see how high-quality FFPE specimens of fatty tissue are possible when using a Revos tissue processor.

The Revos tissue processor features several safeguards for both patient samples and user health:

• Onboard battery backup protects samples during power outages (up to 3 hours).
• Low-temperature rotational processing preserves tissue morphology and nucleic acids.
• Triple filtration of reagent and formamide fumes in storage and reaction chambers.
• Downdraft ventilation removes fumes during operation and maintenance.
• Disposable waste wax drawers eliminate the need to pour hot wax and allow safe solidification and removal.
• Reagent exposure is minimized by eliminating decanting and lifting bottles; only 3 canisters are added at ground level to prevent staff injuries.