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Histology Consumables

Microtome Blades and Cryostat Blades

Obtaining high-quality sections and reducing wasted tissue requires high-quality microtome and cryostat blades. Epredia™ blades offer consistency, durability, and performance with blade coatings and angles to match your application.

Microtome blades and cryostat blades in use

Precision that holds its edge

  • Blades designed for various tissues
  • High- and low-profile blades compatible with most manufacturers’ microtomes and cryostats
  • Steeper bevel angle profile facilitates fast ribboning
  • Enhanced user safety with unique blade box for loading into Epredia E style microtome blade holders

MX35 Ultra+ Low Profile Blade

Section Quality from Start to Finish

Our most advanced microtome blade maintains excellent sectioning quality throughout the blade use with extra-hard blade coatings designed for greater durability and blade longevity.

Explore Low-Profile Microtome Blades
MX35 Ultra+ Microtome Blade in Use
Use of microtome blades and cryostat blades

Designed with user safety in mind

Manage Blades Safely

Epredia's low-profile blade boxes and E-blade holder for rotary microtomes are designed with user safety in mind. Users can load blades directly without the need for touching the blade.

When paired with the blade handling tool, blades can be unloaded and transferred to the blade disposal slot on the blade box.

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Solutions

Products

Low profile microtome blades

Low Profile Blades

Precision that holds its edge - Epredia blades offer consistency, durability, and performance with blade coatings and angles to match your application.
High profile microtome blades

High Profile Blades

Designed for stability and performance – high profile blades provide options with coatings designed for durability.
Steel microtome knife / cryostat knife

Steel Knife

Reusable steel knives can be used with microtomes or cryostats when the technical application dictates that requirement.
HM 355S microtome

HM 355S

A fully automated microtome with four mechanized cutting modes to deliver exceptional sections across an extensive range of specimen types.
HM 340E microtome

HM 340E

A semi-automated rotary microtome combining a mechanized feed with manual cutting.
HM 325 microtome

HM 325

A premier manual rotary microtome with additional capability to support rapid set-up and cleaning for an improved workflow. The HM 325 microtome is designed to take precision sections of tissue specimens.
NX70 cryostat

NX70

Designed to fulfill the needs of both research and clinical laboratories, the CryoStar NX70 cryostat has a form-fitting design, integrated height control, motorized sectioning, object cooling and Peltier fast freeze location.
NX50 cryostat

NX50

Get optimal sectioning quality paired with ergonomics and safety with the Cryostar NX50 cryostat. The NX50 cryostat is designed to accommodate the needs of your routine clinical laboratory.
HM525 NX cryostat

HM525 NX

Deliver high-quality results comfortably and efficiently with the HM525 NX cryostat, a high-performance routine cryostat with intuitive software and touchscreen for simple, efficient operation.

Supporting pathology labs globally

Schedule an On-Site Blade Demo

An Epredia representative will bring microtome and cryostat blades to your laboratory to determine the best Epredia blade for your application. 

Schedule A Demo

FAQs

Many factors affect which blade is best in your application: tissue type, FFPE or fresh-frozen tissue, and the type of paraffin or frozen embedding media used.  If your lab processes a variety of different sample types, consider a blade that performs well in across many different tissue types and applications.

The MX35 Ultra+ blade maintains high quality sections in hard tissue 59% longer than the MX35 Ultra blade, based on internal testing. The Ultra+ blade includes a two-layer extra-hard PTFE layer designed for outstanding longevity.

Microtome and cryostat blade coatings are designed to help produce clean sections with few artifacts and reliable ribboning. Epredia offers a variety of blade coatings for a range of applications. The MX35 Ultra+ blade includes a two-layer coating with an extra-hard PTFE layer designed for durability. Other blades include hard PTFE or soft PTFE coatings.

Histotechs can avoid touching the blade during loading with direct blade loading into Epredia microtome E disposable blade holders when indicated.  Epredia offers a blade removal tool for removing the blade without touching it, and the cartridge includes built-in disposal for used blades.

Epredia offers a range of blade options, including low-profile blades and high-profile blades and a variety of PTFE coating options for performance and durability. Most Epredia blades offer a 34° blade angle for precise ribboning, but a 22° angle blade is also available to facilitate extra-thin sections.

Epredia microtome blades are compatible with most manufacturers’ microtomes and cryostats.

Products available in select geographies globally. Contact your Epredia representative to learn more.

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